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Literature summary extracted from

  • Bang, S.; Chae, H.S.; Lee, C.; Choi, H.G.; Ryu, J.; Li, W.; Lee, H.; Jeong, G.S.; Chin, Y.W.; Shim, S.H.
    New aromatic compounds from the fruiting body of Sparassis crispa (Wulf.) and their inhibitory activities on proprotein convertase subtilisin/kexin type 9 mRNA expression (2017), J. Agric. Food Chem., 65, 6152-6157 .
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.61 5alpha,6alpha-epoxy-(22E,24R)-ergosta-8(14),22-diene-3beta,7beta-diol isolated from fruiting bodies of Sparassis crispa Homo sapiens
3.4.21.61 adenosine
-
 Homo sapiens
3.4.21.61 Berberine
-
 Homo sapiens
3.4.21.61 hanabiratakelide A isolated from fruiting bodies of Sparassis crispa Homo sapiens
3.4.21.61 additional information identification of compounds by NMR spectroscopy Homo sapiens
3.4.21.61 sparoside A isolated from fruiting bodies of Sparassis crispa Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.61 Homo sapiens Q8NBP7
-
-

Synonyms

EC Number Synonyms Comment Organism
3.4.21.61 PCSK9
-
 Homo sapiens
3.4.21.61 proprotein convertase subtilisin/kexin type 9
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.4.21.61 0.00718
-
 pH and temperature not specified in the publication Homo sapiens hanabiratakelide A
3.4.21.61 0.00804
-
 pH and temperature not specified in the publication Homo sapiens Berberine
3.4.21.61 0.00823
-
 pH and temperature not specified in the publication Homo sapiens 5alpha,6alpha-epoxy-(22E,24R)-ergosta-8(14),22-diene-3beta,7beta-diol
3.4.21.61 0.01846
-
 pH and temperature not specified in the publication Homo sapiens adenosine
3.4.21.61 0.0201
-
 pH and temperature not specified in the publication Homo sapiens sparoside A